Sulfonalum
Sulfonal · Clarke - Dictionary of Practical Materia Medica · John Henry Clarke · 3,767 χαρακτήρες · πηγή ↗
General EN
Sulfonal.
Diethylsulphone-dimethyl-methane. (CH3)2C(C2H5S)2. Trituration.
Clinical EN
Albuminuria. Cramps. Cyanosis. Ears, noises in. Epilepsy. Headache, with tinnitus. Haematoporphyrinuria. Locomotor ataxy. Paralysis, ascending. Reflexes abolished.
Characteristics EN
Sulfonal was at first regarded as one of the safest of hypnotics, but many cases of poisoning by medicinal doses have occurred, and my Schema is made up of reported effects produced on patients. The accounts will be found in recent numbers of H. W. Prominent symptoms were: Stupor.
Headache, with noises in ears. Vomiting and diarrhoea. Urine retained, or secretion arrested; claret-coloured; containing albumen; porphyrin. Ataxic gait and diminished or abolished reflexes point to locomotor ataxy.
Ascending paralysis has been observed. The heart is weak; fainting occurs; and death takes place by heart failure. Rashes have been noticed on the skin, purpuric, erythematous, &c. One man (H.
W., xxxii. 174) observed uniform skin effects every time he took Sfo., more intense the larger the dose. This occurred from gr. v.: Patches of erythema appeared (1) first on inner side of first phalanx of right little finger; (2) next over proximal ends of metacarpal bones of left thumb and index; (3) on posterior surface of left forearm a little below elbow;
(4) fourth on prepuce. The symptoms were > by cold douches.
Mind EN
Stupidity.—Unconscious, with dilated and fixed pupils and profuse sweat.
Head EN
Headache and tinnitus aurium.
Eyes EN
Pupils dilated and fixed.
Ears EN
Tinnitus.
Mouth EN
Breath smells of onions.
Face EN
Face livid.
Stomach EN
Vomiting, diarrhoea, and violent chills
Constant retching, vomiting, and soreness over epigastrium
Great disturbance of digestion with scanty urine.
Abdomen EN
Spleen enlarged; hyperaemic.
Stool And Anus EN
Diarrhoea and vomiting.—Great constipation.
Urinary Organs EN
Dark brown urine
Urine very scanty; albuminous; almost solid when cooled
Haematoporphyrinuria and death; urine oscillated between deep claret and light claret colour
Retention of urine; had to be drawn off; dark-coloured
Urine cherry-colour, later like dark port wine.
Male Sexual Organs EN
Erythema on prepuce.
Chest EN
Oedema of lungs.—Signs of broncho-pneumonia.
Heart EN
Death from heart failure and oedema of lungs.—Heart's action feeble, occasionally intermittent.
Back EN
Chronic leptomeningitis, circumscribed softening of dorsal portion of cord, with hypostatic pneumonia of r. lung, and cyanosis of liver and kidneys (post mortem of poisoning cases).
Lower Limbs EN
Gait ataxic; reeled about
Plantar reflex deficient
Paralysis of lower limbs.—(Cramps of legs and single muscles.)
Generalities EN
The symptoms disappear slowly Paralysis of body.—> By cold water; cold douches Great prostration Progressive paralysis affecting legs first then arms
Paralysis sometimes progressive sometimes with hyperaesthesia and abnormal sensation Twitching of muscles, esp. of face and flexors: < by voluntary movement, but always present in sleep Reflexes abolished.—(Epilepsy, inveterate cases with over-excitability of the cortical substance.) Fainted and vomited
Livid, esp. face Cyanosis Death by respiratory failure preceded by unconsciousness.
Skin EN
Discoloured patches like purpura on skin
Patches of erythema, of intensity proportionate to dose:—(1) On inner side of first phalanx of r. little finger;
(2) over proximal ends of metacarpal bones of l. thumb and index;
(3) on posterior surface of l. forearm, a little below elbow;
(4) on prepuce
Erythematous measles-like eruption.
Sleep EN
Stupor
Heaviness and drowsiness
Sleepiness and weariness with unsteady gait.
Fever EN
Violent chills.