Solaninum
Clarke - Dictionary of Practical Materia Medica · John Henry Clarke · 4,660 chars · source ↗
General
Solaninum.
SOLANINUM. An alkaloid obtained from various Solanums, especially S. dulcamara and S. nigrum; also from the Potato plant, S. Tuberosum. C43H69O16. Trituration. Also
SOLANINUM ACETICUM. C43H69O16C2H4O2. Trituration. Solution.
Clinical
Lungs, paralysis of. Tetanus. Ticklishness.
Characteristics
My first practical acquaintance with Solan. was through seeing the excellent effect of Solan. acet. 2 in solution given by Dr. Hughes to a diabetic and semi-paralytic man of 60, who had frequent threatenings of respiratory paralysis with accumulations of mucus which he was unable to expel. Solan. acet. more than any other remedy rescued him from danger and prolonged his life. From that time I have frequently had occasion to use it in similar conditions.
Solan. is obtained from many of the Solanaceae, and especially from Dulcamara. It exists in potatoes, and under certain conditions of germination potatoes may contain a poisonous amount. An accident of the kind occurred to soldiers at Pfuhl who were supplied with potatoes containing about 24 per cent. of Solan. (Med.
Press, June 5, 1901). Sixty-six soldiers had marked poisoning symptoms: Shivering, fever, vomiting, syncope, and in one case convulsions. Skin and conjunctivae were tin-red yellow. Solan. was proved by Clarus and Schroff and others.
Experiments were also made on animals. Slowed and oppressed respiration was a marked feature. Respiration was slowed in inverse proportion to the increase in the pulse rate. There was cerebro-spinal irritation; hyperaesthesia and convulsions < by touch.
Skin more easily tickled than usual. In animals the hind limbs were rigid and paralysed; and in the provers the lower limbs were weakened.
Relations
Compare: Dulc., Bell., S. car., S. nig., S. tub., S. t. aegrot. (Botan). In respiratory paralysis, Dulc., Bell. Sleepy but cannot sleep, Bell. Hyperaesthesia, Nux, Tetanin.
Mind
Stupefaction without previous excitement.
Head
Vertigo
Head: hot, heavy, dull, painful
Pain in occiput.—[(In rabbits:) Injection of cerebro-spinal passages, esp. of medulla oblongata; spasms < by touch; pendulum-like swinging of head and snapping with the mouth.]
Eyes
Pupils slightly contracted.
Mouth
Salivation
The pure alkaloid has a cooling, acid, and salt taste, and when chewed causes a glutinous sensation in pharynx and throat, with scraping which extends to stomach, where it becomes a peculiar sticking pain
Bitter taste.
Throat
Scraping in throat.
Stomach
Constant eructations
Nausea, and diarrhoea; and vomiting
Nausea, violent, ineffectual efforts to vomit
About 5 p.m., vomiting three times without previous nausea, or pain, or any intestinal symptoms.
Abdomen
Rumbling in abdomen.
Urinary Organs
Albumen in urine.
Respiratory Organs
Hoarseness
Respiration: slow; superficial; difficult; oppressed; distressed, esp. on inspiration.—[Decreased frequency of respiration in inverse proportion to increase of pulse
Moist rattle during inspiration
Frequent violent outcry (from action on medulla oblongata)
Masses of mucus in larger air-passages (post mortem)
Paralysis of respiration.
(Rabbits poisoned with S.)]
Chest
[Convulsions of muscles of thorax, with which were soon associated tonic spasms of extremities, at first gentle, gradually increasing, and a short time before death suddenly attaining an enormous height;
< by touch.
(Rabbits.)]
Heart
Pulse: increased in rapidity; weak; thready
Pulse and respiration slowed.—[Increased pulse rate; respiration slowed
Post-mortem, rigidity of heart muscle, all its cavities full of dark, cherry-red coagulated blood.
(Rabbits.)]
Neck And Back
[Cerebro-spinal meningitis. (Rabbits.)]
Lower Limbs
Slight tonic spasms of lower limbs
Weakness of lower limbs.—[Incapable of moving hinder feet forward
Hind legs quite stiff, toes stretched out; then great dejection, retching, and signs of pain.
(Rabbits, from the sulphate.)]
Generalities
Weakness.—Sensitiveness to light, noise, and touch.—Convulsions.—Fainting.—[Sudden rapidity and convulsive embarrassment of respiration, general convulsions, tetanic spasms, and strong dilatation of pupil. (Dog.)]
Skin
Skin dry
Hyperaesthesia; creeping along spine when touching the skin; more easily tickled than natural
Itching
Yellow discolouration of skin.
Sleep
Frequent yawning
Great sleepiness with inability to sleep
Sleep restless, frequently disturbed by frightful dreams
Sleep frequently interrupted without dreams.
Fever
Extremities cold
Shivering, fever, vomiting, and syncope
Profuse perspiration without weakness.